CIHR Open Operating Grants - Fall 2013 Competition

Brian T. Levine

Baycrest Centre

Department of Medicine

Assessing the effects of remote traumatic brain injury on brain aging

           745,484

Ana C. Andreazza

Centre for Addiction and Mental Health

Department of Psychiatry

Identifying peripheral markers of lipid oxidation in mood disorders

           302,853

Anne S. Bassett

Centre for Addiction and Mental Health

Department of Psychiatry

Targeting genetic pathways to schizophrenia

           727,610

Shelley F. McMain

Centre for Addiction and Mental Health

Department of Psychiatry

Dialectical Behaviour Therapy for Chronically Self-Harming Individuals with Borderline Personality Disorder: Evaluating the Clinical and Cost Effectiveness of a Six-Month Treatment

       1,459,322

Arturas Petronis

Centre for Addiction and Mental Health

Department of Psychiatry

Epigenomics of major depressive disorder: dissecting environmental, heritable, and stochastic contributions

       1,191,865

Gary Remington

Centre for Addiction and Mental Health

Department of Psychiatry

Clozapine Levels, Clinical Response, and Side Effects

           442,650

Gillian A. King

Holland Bloorview Kids Rehabilitation Hospital

Department of Occupational Science & Occupational Therapy

Engagement in the Pediatric Rehabilitation Intervention Process: Its Nature, Measurement, and Role in the Determination of Outcomes

           616,109

Unni G. Narayanan

Holland Bloorview Kids Rehabilitation Hospital

Department of Surgery

Outcomes of Hip Interventions for Children with Cerebral Palsy - An International Multi-Centre Prospective Comparative Cohort Study

           678,974

Cathy L. Barr

Hospital for Sick Children

Department of Psychiatry

Genetics of Reading Disabilities

       1,293,293

Jaques Belik

Hospital for Sick Children

Department of Paediatrics

Developmental Programming of Hypertension

           558,395

Catherine S. Birken

Hospital for Sick Children

Department of Paediatrics

Fit for School, Fit for Life - Child Health and School Readiness

       1,256,576

Christopher Caldarone

Hospital for Sick Children

Department of Surgery

Pulmonary Vein Stenosis: Focus on Upstream Vasculopathology

           211,509

Douglas O. Cheyne

Hospital for Sick Children

Department of Medical Imaging

Neural Correlates of Movement Disorders Resulting From Childhood Stroke

           324,854

Peter B. Dirks

Hospital for Sick Children

Department of Surgery

Defining and Targeting Medulloblastoma Intratumoral Diversity

           754,345

James R. Ellis

Hospital for Sick Children

Department of Molecular Genetics

MECP2 function and rescue in neurons derived from Rett syndrome patient iPS cells

           454,990

Sergio Grinstein

Hospital for Sick Children

Department of Biochemistry

Intracellular pH regulation; role in organellar function

           930,223

Patricia Lynne Howell

Hospital for Sick Children

Department of Biochemistry

Synthase dependent exopolysaccharide biosynthesis

       1,178,935

Chi-Chung Hui

Hospital for Sick Children

Department of Molecular Genetics

Iroquois transcription factors in heart development and function

           724,330

Meredith Irwin

Hospital for Sick Children

Department of Paediatrics

Targeting metastatic neuroblastoma

           771,485

Brian Patrick Kavanagh

Hospital for Sick Children

Department of Anesthesia

Ventilator-Induced Lung Injury: Linking gene activation, physiology and outcome

           718,001

Mark R. Palmert

Hospital for Sick Children

Department of Paediatrics

Male-Female Differences in Pubertal Timing: Use of Perturbations of the Lin28/let-7 Axis to Examine Mechanisms

           556,146

Andrew N. Redington

Hospital for Sick Children

Department of Paediatrics

The role of miR-144 in the cardioprotection associated with remote pre-conditioning

           313,056

Padmaja Subbarao

Hospital for Sick Children

Department of Paediatrics

Lung function in preschool children: Utility in diagnosis of asthma

           447,196

Emily Wing Yun Tam

Hospital for Sick Children

Department of Nutritional Sciences

Neurological Outcome of Hypoglycemia in Neonatal Encephalopathy

           703,747

William S. Trimble

Hospital for Sick Children

Department of Biochemistry

Septins as a signaling platform in cancer and metastasis

           807,584

Elysa Widjaja

Hospital for Sick Children

Department of Medical Imaging

Impact of Pediatric Epilepsy Surgery on Health-Related Quality Of Life

           697,292

Isabella Caniggia

Mount Sinai Hospital

Department of Obstetrics & Gynecology

The role of Bcl-2 family members in regulating placental cell fate

           795,820

Daniel Durocher

Mount Sinai Hospital

Department of Molecular Genetics

Understanding DNA repair pathway choice control

           978,785

Ivan George Fantus

Mount Sinai Hospital

Department of Medicine

Tyrosine kinase signaling in the pathogenesis of diabetic nephropathy

           328,836

Allison J. McGeer

Mount Sinai Hospital

Department of Laboratory Medicine & Pathobiology

The epidemiology of the emergence of carbapenemase resistance in Enterobacteriaceae in southern Ontario

       1,067,764

Ravi R. Retnakaran

Mount Sinai Hospital

Department of Medicine

A Randomized Controlled Trial to Evaluate Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes

       1,297,418

Katherine A. Siminovitch

Mount Sinai Hospital

Department of Medicine

Characterization of genetic/molecular pathways underpinning rheumatoid arthritis

           557,784

Andrew Advani

St. Michael's Hospital

Department of Medicine

JAK2 and podocytes in diabetic nephropathy

           672,439

Nancy N. Baxter

St. Michael's Hospital

Department of Surgery

Initiative to Maximize Progress in Adolescent and Young Adult (AYA) Cancer Therapy (IMPACT)

           913,872

Gregory D. Fairn

St. Michael's Hospital

Department of Surgery

Molecular mechanisms generating and maintaining phospholipid asymmetry and its consequences

           634,685

Tom A. Schweizer

St. Michael's Hospital

Department of Surgery

Driving and the aging brain: an immersive fMRI study

           144,553

Sharon E. Straus

St. Michael's Hospital

Department of Medicine

Enhancing Uptake of Systematic Reviews

           305,382

Charles H. Cunningham

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Characterization and Validation of Hyperpolarized Carbon-13 Signals Associated with Heart Failure

           344,523

Dennis Ko

Sunnybrook Health Sciences Centre

Department of Medicine

Assessing and improving the quality of care of patients with out-of-hospital cardiac arrest

           443,022

Bradley J. MacIntosh

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

Achieving brain benefits in covert stroke through aerobic exercise

           360,376

Neil A. Rector

Sunnybrook Health Sciences Centre

Department of Psychiatry

An Examination of Structured Physical Exercise in OCD: Treatment Efficacy, Additive Benefits to CBT, and Cognitive Correlates of Change

           362,414

Baiju R. Shah

Sunnybrook Health Sciences Centre

Department of Medicine

Microalbuminuria and Retinopathy in Gestational Diabetes: The MARIGOLD Study

           229,490

Graham A. Wright

Sunnybrook Health Sciences Centre

Department of Medical Biophysics

MRI for Arrhythmia Management in Ischemic Heart Disease

           820,920

Anna A. Gagliardi

UHN - Toronto General Hospital

Department of Surgery

Safety of medical devices licensed for use in Canada: A mixed methods study to inform policy for effective post-market surveillance

           301,055

Mona L. Gauthier

UHN - Ontario Cancer Institute/PMH

Department of Medical Biophysics

Early events in BRCA1 tumorigenesis

           305,232

Mitsuhiko Ikura

UHN - Ontario Cancer Institute/PMH

Department of Medical Biophysics

Intracellular Calcium Release Channels in Cardiac Arrhythmia and Hypertrophy: Structure and Function

           752,147

Keyvan Karkouti

UHN - Toronto General Hospital

Department of Anesthesia

Blood conservation in cardiac surgery using a novel transfusion algorithm based on point-of-care testing: a stepped-wedge cluster randomized controlled trial

           484,584

Shaf Keshavjee

UHN - Toronto General Hospital

Department of Surgery

Advanced therapeutic strategies for ex vivo repair of lungs for transplantation

           914,350

Thomas Kislinger

UHN - Ontario Cancer Institute/PMH

Department of Medical Biophysics

A Novel Biomarker Discovery Strategy Combining Primary Tumour Xenograft Models and Glyco-Capture of Secreted Proteins

           351,553

Avril Mansfield

UHN - Toronto Rehabilitation Institute

Department of Physical Therapy

Learning not to fall: perturbation training to promote safe independent mobility post-stroke

           340,164

Benjamin G. Neel

UHN - Ontario Cancer Institute/PMH

Department of Medical Biophysics

he Gab/Par pathway in development and cancer

           706,505

Clinton S. Robbins

UHN - Toronto General Hospital

Department of Laboratory Medicine & Pathobiology

Local Proliferation Dominates Lesional Macrophage Accumulation in Established Atherosclerosis

           626,770

Gary M. Rodin

UHN - Princess Margaret Hospital

Department of Psychiatry

Emotion And Symptom-focused Intervention (EASI) for Individuals with Acute Leukemia

           249,692

Elise F. Stanley

UHN - Toronto Western Hospital

Department of Physiology

The Presynaptic Calcium Channel and Synaptic Vesicle Tethering

           792,875

Eldad Zacksenhaus

UHN - Toronto General Hospital

Department of Medicine

A model for Group C Medulloblastoma induced by deletion of RB1 and p53 tumor suppressors

           486,928

Gang Zheng

UHN - Ontario Cancer Institute/PMH

Department of Medical Biophysics

Improving cure rate of early stage lung cancer with personalized nanomedicine

           695,400

Liliana Attisano

Campus

Department of Biochemistry

Signalling pathway mediated control of cytoskeletal remodelling in neurons

           812,660

Liliana Attisano

Campus

Department of Biochemistry

Identifying novel regulators of oncogenic TAZ and YAP in breast cancer

           750,595

Denise D. Belsham

Campus

Department of Physiology

Sensing of Peripheral Nutrient Status by the Hypothalamus- from Rodents to Humans

           889,793

Michelle P. Bendeck

Campus

Department of Laboratory Medicine & Pathobiology

The Role of Discoidin Domain Receptor 1 (DDR1) in Vascular Calcification of Atherosclerosis and Diabetes

           574,358

Grant W. Brown

Campus

Department of Biochemistry

Mechanisms of Genome Instability

           947,528

Andrew N. Emili

Campus

Donnelly Centre

WormMap: Mapping High-Quality Protein Complex 'Interactomes' in C. elegans

       1,267,460

Alexander W. Ensminger

Campus

Department of Molecular Genetics

Functional genomic dissection of Legionnaires' disease outbreaks

           698,323

Barbara E. Funnell

Campus

Department of Molecular Genetics

Mechanisms of action of ParA and ParB proteins in bacterial plasmid segregation

           693,590

Lewis E. Kay

Campus

Department of Molecular Genetics

Pushing the NMR Envelope: Studies of the Proteasome and its Partners

       1,349,810

Young-In J. Kim

Campus

Department of Medicine

Epigenetic, molecular and cellular effects of folic acid supplementation in the susceptible periods of the life cycle

           692,395

Henry M. Krause

Campus

Donnelly Centre

Genome-wide analysis of mRNA trafficking

       1,063,695

Evelyn K. Lambe

Campus

Department of Physiology

Prefrontal attention circuitry: Mechanisms of deregulation and restoration in brain disorders

           717,745

Jeffrey E. Lee

Campus

Department of Laboratory Medicine & Pathobiology

Characterization of human cellular restriction factors that target HIV-1 replication

           602,545

Fiona A. Miller

Campus

Health Policy, Management & Evaluation

Pathways to procurement: Processes, rationales and options for investing in health technology innovation

           354,718

Justin R. Nodwell

Campus

Department of Biochemistry

Discovery of antibiotics by genetic manipulation of environmental microbes

           750,130

Peter J. Roy

Campus

Department of Molecular Genetics

Exploiting Caenorhabditis elegans as a Platform for Novel Drug and Target Discovery

       1,235,955

Maria Rozakis-Adcock

Campus

Department of Laboratory Medicine & Pathobiology

Role of PHIP in the Hormonal Control of Liver Gluconeogenic Networks

           444,472

Ali Salahpour

Campus

Department of Pharmacology & Toxicology

Identification and In vivo characterization of Trace Amine Associated Receptor 1 (TAAR1) Antagonists

           712,614

Tania H. Watts

Campus

Department of Immunology

TNFR family members in control of respiratory influenza virus infection

           796,370

Gillian A. Hawker

Women's College Hospital

Department of Medicine

Towards Better Surgical Outcomes through Improved Decision Making about Appropriateness for Total Knee Arthoplasty in Patients with Knee Osteoarthritis

           764,425

Simone N. Vigod

Women's College Hospital

Department of Psychiatry

An electronic decision aid for antidepressant use in pregnancy: a pilot randomized controlled trial

           128,425